Objective To explore the rules of acupoint selection in acupoint plaster therapy for diabetic peripheral neuropathy (DPN) patients, and to provide reference for nurses′ practice of acupoint plaster therapy. Methods The China Knowledge Network, PubMed and other databases were searched for literature related to acupoint plaster therapy for DPN from database inception to February 2021, and Lantern 5.0 and Weka 3.8.5 were used to perform latent structure analysis and data mining to determine the acupoint-prescription association rules. Results A total of 43 publications were included, involving 3,685 patients, 122 symptoms and 37 acupoints.The most commonly used acupoints were Zusanli, Sanyinjiao, etc., and the most prevalent symptoms were limb numbness, limb pain, fatigue, etc.The results of data mining showed that the highly supported association rule of acupoints was Zusanli-Sanyinjiao. Latent structure model showed that the main syndrome patterns were Yin-deficiency and blood-stasis, liver-and-kidney-deficiency, phlegm and blood stasis, etc.The frequent item set identified 8 rules for symptoms-acupoints and 4 rules for symptoms-syndrome pattern-acupoints. Conclusion Zusanli, Sanyinjiao, Yanglingquan and Yongquan are the main acupoints for acupoint plaster therapy in DPN patients, and specific acupoints could be added according to the syndrome pattern.