Objective To evaluate the implementation effect of a family function-oriented caregiver support intervention program for family caregivers of first-episode stroke patients. Methods A total of 103 caregivers of patients with first-episode stroke were conveniently selected and chronologically divided into a control group of 51 and an intervention group of 52, receiving either conventional care or family function-oriented caregiver support intervention for 3 months.The caregiver home care readiness, comprehensive caregiving ability and family function were compared between the two groups. Results The home care readiness at discharge was significantly higher in the intervention group than that in the control group (P＜0.05). Significant group effect, time effect and group-by-time interaction effect were observed in the total score and dimension scores of comprehensive caregiving ability, as well as in the score of family function (all P＜0.05). Conclusion The implementation of a family function-oriented caregiver support intervention program can improve stroke caregivers′ home care readiness, comprehensive caregiving ability and family function, which can help patients better transition from hospital to home.