Objective To compare the voice function and psychological status in post-stroke patients with or without swallowing disorders, and to provide a reference for developing targeted rehabilitation strategies. Methods A total of 337 stroke patients were selected by convenance sampling and divided into a dysphagia group (n=122) and a normal swallowing group (n=215) after the Water Swallow Test and Standardized Swallowing Assessment.The Grade, Roughness, Breathiness, Asthenia, and Strain (GRBAS) scale, the Voice Handicap Index-10 (VHI-10) and the software Praat were used for subjective and objective voice function assessment, and the Hospital Anxiety and Depression Scale was used to assess the psychological status. Results There were significant differences in the scores of grade, roughness, breathiness, and asthenia, as well as in the VHI-10 score and the objective acoustic indexes between the dysphagia group and the normal swallowing group (all P＜0.05).The anxiety and depression scores also had significant differences between the dysphagia group, and the normal swallowing group (all P＜0.05). Conclusion Patients with dysphagia after stroke have impaired voice function, and severe anxiety and depression than those with normal swallowing, so swallowing-voice-psychological combined rehabilitation is needed.