Objective To construct an emergency psychological service system for nurses in general hospital under major public health emergencies, and to provide reference for nurses′ mental health service in this situation. Methods Based on literature analysis and phenomenological research, an expert consultation questionnaire was initially developed.Then a 2-round Delphi study was conducted among 35 experts in the field of mental health service, hospital management, nursing management and emergency management, etc. Results Experts′ response rate was 94.29% and 90.91% in the first and second round, experts′ authority coefficient was 0.83 and 0.84, and the Kendall coefficient of concordance was 0.16 and 0.20 respectively (P＜0.01 for both).The final system was consisted of 4 first-level indicators, 19 second-level indicators, and 36 third-level indicators. Conclusion The reliability and practicability of the emergency psychological service system for nurses in general hospital under major public health emergencies are high, which can provide reference to offer systematic and complete psychological services for nurses when public health emergencies occur.