Objective To deeply understand the work pressure felt by nurses booked online for in-home catheter care, to explore measures to relieve their pressure, and to provide a reference for promoting the development of online appointment for catheter care. Methods Purposive sampling method was used to select 11 nurses who dealt with online appointments for in-home catheter care to partake in in-depth interviews. Colaizzi′s 7-steps analytical method was used for interview data analysis. Results Three themes were extracted:① the stressors were from patients, insufficient safety measures, and the nurses themselves;②the nurses had positive and negative feedback regarding work pressure; ③there were 2 levels of copings against work pressure, individual versus managerial. Conclusion Nurses booked online for in-home catheter care experienced diversified sources of pressure. All parties should work together to mitigate nurses′ work pressure, in an effort to promote the development of online appointment based catheter care, and improve the quality of nursing services.