Objective To investigate the status of thriving at work among nurses, and to explore its influencing factors. Methods Totally, 427 nurses in 3 grade A hospital in Jinan city were selected by convenience sampling methods, and were surveyed with a demographic questionnaire, the Thriving at Work Scale, the Survey of Nurse Perceived Organizational Support and the Feedback-Seeking Behavior Questionnaire. Results The nurses scored (53.67±9.73) points in thriving at work, which was positively correlated with the total score of organizational support, total score of feedback seeking behavior, and scores of all dimensions (P＜0.01 for all). Multiple linear regression analysis showed that whether nurses like nursing job, organizational support, and feedback-seeking behaviors were the influencing factors for nurses′ thriving at work (P＜0.05,P<0.01), with the above-mentioned variables accounting for 56.7% of the total variation. Conclusion Nurses′ thriving at work was at medium level. Measures should be taken to improve the level of nurses′ thriving at work, promote the growth and development of nurses and improve organizatio-nal effectiveness.