Objective To explore current situation and influencing factors of medical adhesive-related skin injury (MARSI) in elderly patients in ICU. Methods Totally, 289 elderly patients in ICU were selected and occurrence of MARSI in the patients during ICU stay was assessed and documented. Factors associated with MARSI were probed. Results A total of 29 elderly patients had MARSI during the observation period，with the incidence rate at 10.03%. Binary logistics regression analysis showed that elderly patients who had diabetes, who were given sedatives, who had nutritional risks, low body weight, or hypoproteinemia were at higher risk of MARSI （P<0.05，P<0.01）. Conclusion Elderly patients in ICU are a high-risk group for MARSI. Measures should be taken to target the risk factors , in an effort to ward off MARSI in the population.