Objective To observe the effects of "Wu Yin Tiao Shen" technique on mood and sleep quality in patients with mild to moderate post-ischemic stroke depression (PISD). Methods PISD patients were randomly divided into two groups. The cognitive therapy group (n=35) received cognitive treatment, while the WuYinTiaoShen group (n=36) received acupuncture at Baihui, Yintang and Shenting combined with five-element music treatment in Angle mode. Before and after intervention, the Pittsburgh Sleep Quality Index (PSQI), the Hamilton-24 Depression Scale (HAMD-24), and polysomnography were used to measure and compare the efficacy of the two groups. Results The post-intervention depression scores in both groups saw significant drops from before (P<0.01 for both). There was no statistical significance in the improvement rates of depression and sleep between the two groups （P>0.05 for both）. The results of polysomnography showed that the total sleep time, REM latency and sleep efficiency increased significantly, the sleep latency time and wake-up time were shortened significantly, and the number of wake-ups decreased significantly in both groups after treatment, and the changes in sleep process in the WuYinTiaoShen group were more significant than those in the cognitive treatment group （P<0.05,P<0.01）; the sleep time of N1, N2, N3 and REM stage was prolonged, the proportion of N1 and N2 stage sleep was decreased, and the proportion of N3 and REM stage sleep increased in both groups after treatment, with the WuYinTiaoShen group significantly better than the cognitive treatment group (all P<0.01). Conclusion "Wu Yin Tiao Shen" technique can significantly improve depressive mood and insomnia symptoms in patients with depression after ischemic stroke.