Objective To understand the current status of postpartum fatigue and mother-infant attachment, the relationship between the 2 variables, and to provide references for targeted nursing interventions. Methods A sample of 210 postpartum women were selected and surveyed with a general data questionnaire, the Postpartum Fatigue Scale (PFS), the Maternal Postnatal Attachment Scale (MPAS), the Edinburgh Postpartum Depression Scale (EPDS), the Perceived Social Support Scale (PSSS) and the Pittsburgh Sleep Quality Index (PSQI). Results The women scored (15.70±2.98) points in postpartum fatigue, and (74.82±6.43) points in mother-infant attachment, with the 2 variables negatively correlated (P<0.01). Multiple linear regression analysis showed that, sleep quality, depression, parity, age, family per capita monthly income significantly weighed on postpartum fatigue（P＜0.05，P＜0.01）; postpartum fatigue, infant crying frequency, social support and depression took significant weight on mother-infant attachment （P＜0.05，P＜0.01）. Conclusion Women experienced moderate level of fatigue 6 weeks post partum. Postpartum fatigue and mother-infant attachment are influenced by many factors. Postpartum fatigue has damaging effect on mother-infant attachment. Interventions targeting postpartum fatigue should be taken to mitigate postpartal women′s fatigue levels.