Objective To investigate the level and related factors of job embeddedness among nurses in the anesthesiology department, and to provide reference for managers to support and cultivate nurses in anesthesia nursing. Methods Totally, 412 nurses working in the department of anesthesiology were investigated by using a general information questionnaire, the Global Job Embeddedness Scale, Nurses′ Intention to Remain Employed Scale and Practice Environment Scale. Results The sample scored 22.87±4.18 on job embeddedness, 22.50±4.10 on retention intention and 82.94±13.64 on work environment.Multiple linear regression analysis showed that nursing foundations for quality of care, retention intention, nurse manager ability and leadership, annual income, and hospital grade were predictors of job embeddedness (P＜0.05,P＜0.01). Conclusion Job embeddedness of nurses in the anesthesiology department is at a medium level. It is necessary to improve the nursing management system, establish management framework for anesthesia nursing, enhance anesthesia nursing management level, ensure nurses′ reasonable income, strengthen their professional identity and equity, and improve their intention to stay, so as to increase the job embeddedness level.