Objective To enhance the effect of endocrinology specialty training for nurses and the level of specialist care. Methods Problems in nursing practice in the endocrinology department were identified for training, then simulation problem-based learning (S-PBL) in combination with WeChat-delivered daily lessons were provided for 17 nurses.After two rounds of training (about 8 months), the effect was evaluated. Results Clinical nursing ability of nurses was significantly improved after the training （P＜0.01 for all）. More than eighty percent (82.4%-100%) of the nurses gave positive feedbacks on the training. Conclusion S-PBL in combination with WeChat daily lesson can effectively improve the effect of endocrinology specialty training for nurses, thus to enhance nursing quality.