Objective To explore the application effect of the escape room teaching model in clinical practice teaching in department of cardiovascular medicine for baccalaureate nursing students. Methods Ninety-six baccalaureate nursing students practicing in cardiovascular medicine department of a tertiary hospital were selected using convenient sampling method, and numbered chronologically, those numbered 1-48 were taken as a control group, and others numbered 49-96 were regarded as an experimental group. The control group adopted conventional clinical practice teaching, while the experimental group additionally adopted escape room teaching model. After the practice teaching, the critical thinking ability, learning engagement and examination score of the two groups were evaluated. Results After the teaching, the critical thinking ability score, the learning engagement score and examination score of the experimental group were significantly better than those of the control group (P<0.05,P＜0.01). Conclusion Application of escape room teaching model in clinical practice teaching in baccalaureate nursing students, can stimulate the students actively engage in learning and effectively improve clinical practice teaching effect.