Objective To investigate the status of return-to-work among survivors of hematopoietic stem cell transplantation （HSCT）, and to analyze its influencing factors, so as to provide reference for targeted intervention. Methods A total of 126 survivors of HSCT were investigated utilizing a demographic information questionnaire, the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and the Medical Outcomes Study Social Support Survey(MOS-SSS). Results Totally 50 participants (39.68%) had returned to work. The prevalence of fatigue was 50.79%, and the total MOS-SSS score was 62.37±9.47. The results of logistic regression indicated that, fatigue, duration after transplantation and educational background were the major influencing factors of return-to-work in survivors of HSCT (P＜0.05，P＜0.01). Conclusion The incidence of return-to-work among HSCT survivors is low. Medical staff should take measures according to its major influencing factors, so as to help the survivors return to work safely and permanently, then get back into a normal life.