Objective To explore the application effect of checklist management in cardiac rehabilitation of patients with acute myocardial infarction after percutaneous coronary intervention (PCI). Methods Totally 572 acute myocardial infarction patients undergoing PCI were divided into an intervention group (n=279) and a control group (n=293) using a random number table. The control group adopted the routine management model, while the intervention group used the checklist management model in cardiac rehabilitation. The improvement of cardiac function, the number of cardiovascular events in hospital and frailty score between the two groups were compared. Results The improvement of left ventricular ejection fraction of the intervention group was significantly better than that of the control group, and its incidence of heart failure and cardiac arrhythmia, and the frailty score were significantly lower than those of the control group (P<0.05, P<0.01). Conclusion The implementation of checklist management model in cardiac rehabilitation of acute myocardial infarction patients after PCI, can improve patients′ cardiac function, reduce the incidence of cardiovascular events during hospitalization, improve the patient′s debilitating symptoms，and improve their rehabilitation.