Objective To explore the effect of hydrocolloid for closure without suture combined with negative pressure wound therapy (NPWT) in patients with fat liquefaction after liver transplantation. Methods A total of 47 patients with fat liquefaction after liver transplantation were divided into two groups chronologically, the 26 patients hospitalized from February 2017 to July 2018 were defined as a control group, and other 21 patients hospitalized from August 2018 to December 2019 were regarded as an intervention group. The two groups received wound assessment and routine wound bed preparation, and the control group was treated with conventional dressing change, while the intervention group was treated with hydrocolloid for closure without suture combined with NPWT. Results The wound healing time, total healing speed, total wound dressing time, dressing frequency, treatment cost, change of wound area per unit time, change of wound depth per unit time, wound healing speed per unit time etc. between the two groups were significantly different (P<0.01 for all). Conclusion Hydrocolloid for closure without suture combined with NPWT promotes the healing of fat liquefaction wound after liver transplantation, it doesn't add economic burden, and it reduces nursing work load.