Objective To improve the quality and efficiency of intravenous (IV) fluid therapy in the hospital. Methods We formed a management team for IV therapy,developed nursing-sensitive indicators for IV therapy, and created a structured information technology platform for IV therapy. Time for analysis of sensitive indicators by nurses, accurate rate of sensitive indicators and changers of 7 sensitive indicators were compared before and after application of the platform. Results Time for analysis of sensitive indicators by nurses was significantly decreased, but the accurate rate was significantly enhanced after application of the platform (P<0.01 for both). Quality of the 7 sensitive indicators was also significantly improved (P<0.05, P<0.01). Conclusion The application of information technology platform effectively improves management efficiency of IV therapy and reduces incidence of adverse events, which achieves the goal of accurate and efficient management.