Objective To develop an evidence-based practice protocol for home care of the stroke patient, and to provide a guide for nurse follow-up. Methods We searched foreign and domestic electronic databases to retrieve the best evidence of family caregiving for patients with stroke and to form recommendations, then we wrote draft of evidence-based practice protocol for home care of the stroke patient, and conducted two rounds of expert consultation. Results The protocol was composed of 40 items, including six aspects of organizational management, nursing assessment, goal setting, family management, patient-centered service and remote service. And problem evaluation list and practice process were formulated based on the protocol. The return rate of questionnaires was 93.75% in round 1 and 100% in round 2 of expert consultation. The authority coefficients of two rounds were 0.805 and 0.810, respectively. The Kendall′s coefficients of concordance W were 0.326 and 0.442 in round 1, 0.422 and 0.456 in round 2(P<0.01 for all), respectively. Conclusion The process of developing home care practice protocol for stroke patients is standar-dized and rigorous, and the content is comprehensive, which can be used in the practice of home care for stroke patients.