Objective To reduce the incidence of venous thromboembolism (VTE) in patients undergoing radical cystectomy. Methods Patients with bladder cancer who were scheduled for radical cystectomy were divided into two groups. A total of 168 patients admitted between June and November 2019 were treated as the control group and received routine VTE prevention measures. Their counterparts admitted from June to November 2020 (172 patients) were served as the observation group and subjected to graded VTE prevention protocol：building doctor-nurse cooperative prevention team, embedding Caprini score into hospital information system to achieve VTE risk warning, and implementing graded prevention measures according VTE risk level. The incidence of postoperative VTE, the concentration of D-dimer on postoperative day 3, bedridden time and length of hospital stay were compared between the two groups. Results The observation group had lower incidence of postoperative DVT, decreased level of D-dimer, and shorter bedridden time and length of hospital stay compared with the control group (P＜0.05，P＜0.01). Conclusion Implementation of graded VTE prevention can significantly reduce VTE, ensure patient safety, shorten postoperative bed stay and hospital stay, thus to promote recovery of patient safter radical cystectomy.