Objective To evaluate the practice effect of part time nurses management strategy, and to analyze its economic effect. Methods A total of 109 part time nurses and 109 full time nurses from a hospital were selected by propensity score matching method. The full time nurses worked in fixed departments, and they were paid monthly, while the part time nurses additionally provided services by taking orders in outpatient department, and they were paid extra by the hour.Results The scores of professio-nal benefits,occupational well-being, work satisfaction of part time nurseswere significantly higher than those of full time nurses (P＜0.05，P＜0.01）. After applying part time nurses, the benefit-cost ratio was 1.264, the cost-effectiveness ratio for part time nurses and full time nurses was 0.086and 0.200 in professional benefit, and it was 0.134 and 0.321 in occupational well-being.The cost-effectiveness ratio of the increment in professional benefits and occupational well-being was -3.499 and -3.030. Sensitivity analysis showed that, the cost change of each sensitive indicators was within 10%, and no reverse was noticed. Conclusion Applying part time nurses is conducive to improving nurses′ professional benefits, occupational well-being and work satisfaction, and realizing a tripartite win-win situation of hospital, departments and nurses in economic benefits.