Objective To explore the effect of running a team for management of visitors and inpatients attendants in general hospitals while carrying out regular COVID-19 prevention and control. Methods A multi-disciplinary team was composed of personnel from the Departments of Nursing, Infection Control, and Network and Information Center, etc., and was designated to manage visitors and inpatients attendants. The team members cooperated to formulate rules and regulations, improve process, conduct training and supervision, and design electronic identification (ID) card for inpatients and attendants. The effect was evaluated after 6 months of intervention. Results The total surveillance counts were 22 147, and the implementation rate of "one patient having one attendant" was 99.34%. The overall patient satisfaction and satisfaction with the hospitalization environment were significantly enhanced, whereas the elevator single trip time and the number of passengers were significantly reduced (P＜0.01 for all）. The electronic ID cards were utilized in 53 nursing units, with the total usage counts of 76 116. Training on how to use the electronic ID card was completed in the rest nursing units that would be scheduled to use it. Conclusion Running a team for management of visitors and inpatients attendants in general hospitals meets the requirements of COVID-19 prevention and control, which can benefit not only the medical staff but also the patient.