Objective To explore the effect of Huo-Long cupping therapy on alleviating sleep disturbance in women during the perimenopause with the pattern of disharmony between the heart and kidney. Methods A total of 69 perimenopausal women having sleep disturbance with the pattern of disharmony between the heart and kidney were randomly divided into a control group of 34 and anintervention group of 35, receiving either routine acupuncture therapy or Huo-Long cupping therapy once every 3 days, successively for 10 times. The improvement in sleep disturbance was measured post-intervention, and the Pittsburgh Sleep Quality Index (PSQI) was utilized to evaluate sleep quality pre-, immediately and 1 month post-intervention. Results The intervention group had higher improvement in sleep disturbance compared with the control group after the intervention （P＜0.05). The intervention group had significantly lower PSQI scores immediately and 1 month post-intervention compared with the control group (P<0.05 for both). The post PSQI score in the control group was significantly decreased but significantly increased during the follow-up period (P<0.05 for both). The post PSQI score in the intervention group was also significantly decreased (P<0.05) and maintained at a stable level during the follow-up period. No adverse events were observed in both groups. Conclusion Huo-Long cupping therapy can effectively and safely improve sleep quality in patients with perimenopausal insomnia of disharmony between the heart and kidney, and the effect is relatively persistent.