Objective To identify risk factors of pressure injury in advanced cancer patients and to quantify the risk of each factor by using risk matrix method, so as to provide reference for management of pressure injury in advanced cancer patients.Methods Based on the theory of risk matrix, the risk matrix of pressure injury in hospitalized patients with advanced cancer was constructed by literature research, Delphi expert consultation and questionnaire survey. Results There were 12 extremely high risk factors, 19 high risk factors, and 15 medium risk factors. The overall risk index was 9.87±1.27, with patient dimension of 10.43±5.88, nurse dimension of 11.34±1.18, nursing technology and equipment dimension of 9.93±1.39, management system dimension of 5.58±2.12, and nursing environment dimension of 7.76±0.95. Conclusion The risk matrix of pressure injury in hospitalized patients with advanced cancer can visually and scientifically reflect risk level of the patient. 