Objective To explore the effect of intimacy enhancement therapy on reproductive concerns in female breast cancer patients of childbearing age. Methods Female breast cancer patients during the childbearing years were enrolled and assigned into a control group of 53 or an intervention group of 52 according to the wards they hospitalized. The control group were given conventional health education, while the intervention group received 4 weeks of intimacy enhancement therapy additionally. The Reproductive Concerns After Cancer Scale (RCAC) and the Quality of Relationship Index (QRI) were used to evaluate the effect before and after the intervention. Results The intervention group had higher QRI score and lower RCAC score compared with the control group (P<0.01 for both). Conclusion The intimacy enhancement therapy can effectively increase satisfaction of intimate relationships and relieve reproductive concerns of childbearing-age women with breast cancer.