Objective To discuss the effect of aiding nursing specialty construction in ethnic minority areas under the background of targeted poverty alleviation. Methods By means of forum, on-site visits and field work, questionnaire survey, and literature reading, we found out the shortcomings in nursing specialty construction in Nujiang Vocational Education Centre, which was the target of the aiding program .Then we formed a quadrilateral coordination working team, which designed a triune scheme (grass roots oriented, rehabilitation featuring, mid-to-high connection) for nursing profession construction, innovated a "2-way multi-post" faculty support system, and built a co-construction mode of practice platform. Results After support, the school′s nursing qualification examination passing rate, employment rate, job suited rate were all higher than before （P＜0.01 for all）; graduated students′ satisfaction with the school enjoyed a significant elevation from before （P＜0.01 ）; the number of prize-wining by the teachers and students, and the quality of the prizes, and teachers′ publications also enjoyed an elevation from before. Conclusion Effective support system could help enhance the level of nursing specialty construction in ethnic minority areas, and boost cultivation quality of nursing talents.