Objective To explore the efficacy of evidence-based nursing practice for construction of an early off-bed activity process for primary liver cancer patients after transcatheter arterial chemoembolization (TACE）. Methods Eighty patients with primary liver cancer who underwent scheduled TACE procedure were evenly and randomly divided into a control group and an intervention group.The control group received routine nursing care, while the intervention group were additionally subjected to an early off-bed activity process for primary liver cancer patients after TACE which was built through evidence-based nursing methodology.The time to start off-bed activity, incidence rates of postoperative complications and Self-Rating Anxiety Scale （SAS） scores were compared between the two groups. Results The intervention group started off-bed activity significantly earlier than the control group;the incidence rates of postoperative pressure injury, fever, and back pain, and SAS scores on the 3rd postoperative day in the intervention group were significantly lower than those of the control group （P＜0.05，P＜0.01）. Conclusion The early off-bed activity process for primary liver cancer patients after TACE constructed through evidence-based nursing methodology can shorten the time to start off-bed activity, reduce the incidence rates of postoperative pressure injury, fever, and back pain, and mitigate anxiety levels.