Objective To investigate the status and analyze the influencing factors of the willingness of participation in health care among transitioning adolescents with epilepsy. Methods A convenient sampling method was used to select 428 transitioning adolescents with epilepsy （12-18 years old）.The adolescents were surveyed with the Willingness of Patient Participation in Health Care Scale, the Social Support Rating Scale and the Adolescent Health Care Self-Efficacy Scale. Results The total score of the willingness of adolescent participation was （124.39±16.82）, with the dimensions in descending order being decision about seeking medical help, requests, inquiry and supervision, information interaction, treatment and care, and diagnosis and treatment decision.The multivariate linear regression analysis showed that ages, course of disease, type of epileptic attack, numbers of comorbidities, type of family structure, social support and level of self-efficacy contributed to influence willingness of adolescent participation in health care （P＜0.05，P＜0.01）. Conclusion Willingness of participation in health care among adolescents with epilepsy was at a medium level.Adolescents with older age, longer disease course, mixed type of epileptic attack and mobile family structure had higher willingness to participate in health care.Providing multi-angle social support to improve self-efficacy of epileptic adolescents, is helpful to enhance adolescent participation in health care, and finally smooth the transition from children to adults.