Objective To evaluate and integrate available evidence on prevention of peripheral phlebitis related to amiodarone infusion,and to provide references for clinical intervention strategies. Methods Using the method of evidence-based nursing, we systematically searched for evidence on prevention and nursing of peripheral phlebitis related to amiodarone infusion, including guidelines, systematic reviews, expert consensus report, best practices report, evidence summary report, clinical decision report, and original studies.The publications were retrieved from the inception of databases to May, 2020.Two authors independently assessed quality of the included publications and extracted data. Results A total of 10 publications were included, encompassing 1 guidelines, 1 expert consensus report, 6 systematic reviews, 2 randomized controlled trials.Totally, 18 pieces of best evidence from six aspects were summarized:assessment of peripheral phlebitis, intravevous cannulation, intravevous cannula replacement, infusion management, treatment of infusion phlebitis, supervision and training. Conclusion The summarized best evidence on prevention and nursing care of patients developing peripheral phlebitis related to amiodarone infusion, and the formed recommendations can provide reference for nurses to establish relevant nursing plans.