Objective To explore the effects of homogenous management for diabetic patients admitted to non-endocrinological specialties by establishing a diabetes specialist group. Methods A prospective, non-contemporary controlled design was adopted.A total of 79 diabetic patients selected from 81 clinical units in September, 2016,were assigned into the before group and received routine care.Hence, a diabetes specialist group was established, and 81 diabetes liaison nurses were picked from 81 clinical units.Then a 3-tier intra-hospital blood glucose management mode (quality control branch of the diabetes specialist group-unit quality control group-unit liaison nurse) was established and homogeneous management for all the diabetes patients in the hospital was implemented. Two years into homogeneous management, another 80 diabetic patients selected from 81 clinical units in September, 2018,were assigned into the after group. Before and after homogeneous management, liaison nurses and the patients were mea-sured for diabetes knowledge levels, and the patients′ blood sugar level was measured at discharge. Results After establishment of the diabetes specialist group, liaison nurses had higher diabetes knowledge and skills levels than before (P＜0.01 for both); the after group patients had higher diabetes knowledge levels, and lower fasting blood sugar level at discharge, than the before group (P＜0.01 for both). Conclusion The diabetes specialist group has played a significant role in homogeneous management of diabetic patients admitted to non-endocrinological specialties.It also help improve diabetes knowledge and skills levels of nurses working in non-endocrinological departments, as well as diabetes knowledge level of diabetic patients, and lower patients′ fasting glucose levels.