Objective To summarize the best evidence on long-term home oxygen therapy (LTOT) for patients with chronic obstructive pulmonary disease (COPD), and to provide guidance for LTOT practice. Methods Computerized search in such websites and databases as the National Guideline Clearinghouse（NGG）, the American Thoracic Society（ATS）, British Thoracic Society（BTS）, Irish Thoracic Society（ITS）, Thoracic Society of Australia and New Zealand（TSANZ）, Cochrane Library, PubMed, JBI,BMJ, etc, was conducted to collect relevant guidelines, expert consensus reports, evidence summary reports, systematic reviews and randomized controlled trials on LTOT for COPD patients. Two researchers extracted and summarized the evidence from publications that met the quality standards. Results A total of 10 publications (5 guidelines, 1 clinical decision, 1 expert consensus report, 1 systematic review, 2 randomized controlled trials) were included, leading to the formation of 25 pieces of best evidence, which generated such 10 themes as LTOT indications, contraindications, oxygen therapy principles, patient assessment and monitoring, LTOT plan, quality control, precautions, and health education, etc. Conclusion It is recommended that medical staff follow the best evidence to develop individualized LTOT management for COPD patients and promote evidence-based practice.