Objective To evaluate the effect of horticultural program on the quality of life of patients on maintenance hemodialysis therapy. Methods A total of 62 patients on maintenance hemodialysis therapy were randomized into a control group of 30 cases, who received routine hemodialysis care, and an intervention group of 32, who were additionally subjected to a horticultural therapy intervention program, which had 3 cycles (4 weeks a cycle), stretching 12 weeks.Patients were evaluated for quality of life before the intervention, 4 and 12 weeks into the intervention. Results Four weeks into the intervention, the intervention group had higher mental state scores than the control group; 12 weeks into the intervention, the intervention group had higher scores in physical state, mental state, burden of kidney disease, symptoms of kidney disease, and the influence of kidney disease on daily life, and higher QOL scores, than the control group （P＜0.05,P＜0.01）. Conclusion Horticultural program is beneficial to improve the quality of life of patients on maintenance hemodialysis therapy.