Objective To investigate the effects of psychomotor rehabilitation theory based intervention on senile dementia patients. Methods Forty-four patients with senile dementia were divided into an observation group （n=21） and a control group （n=23）.Both groups received routine nursing care.On this basis, the observation group was given psychomotor rehabilitation theory based intervention for 24 weeks, including a multi-sport plan, multi-sensory stimulation therapy, and efforts aiming to improve physiological and psychological disorders. Before and after the intervention, the effects were evaluated by using the Mini-Mental State Examination （MMSE）, the Barthel Index（BI） and the Cornell Scale for Depression in Dementia （CSDD）. Results After intervention, MMSE scores of memory, recall, language and visual spatial skills and BI scores in the observation group were significantly higher than those in the control group, while the CSDD scores of the observation group were significantly lower than those of the control group （P＜0.05,P＜0.01）. Conclusion Psychomotor rehabilitation theory based intervention can improve part of the cognitive function and ADL of senile dementia patients, and alleviate their depressive symptoms.