Objective To identify the barriers to the delivery of home-based end-of-life care in Shanghai, and to rank the priority level and feasibility of solving these barriers, thus to provide reference for advancing home-based end-of-life care. Methods Following the guidance of concept mapping approach, barriers to the delivery of home-based end-of-life care were determined through qualitative interviews and literature review, then priority level and feasibility of solving these barriers were rated by healthcare professionals. Finally, multidimensional scaling and hierarchical cluster analysis were conducted to generate the concept map. Results Fifty healthcare professionals from community health service center or administrative faculty participated in the study. Sixty-one barriers were identified and grouped into five clusters: staff competency and practice setting (mean score of priority=4.93, mean score of feasibility=4.38); service design (priority=5.08, feasibility=4.30); medical expenses and staff rewards (priority=5.62, feasibility=4.40); patient and family attitudes and knowledge (priority=5.07, feasibility=4.27); and miscellaneous barriers (priority=4.42, feasibility=3.69). Conclusion Considering the priority level and feasibility, the issues of medical expenses and staff rewards should be solved first. It is recommended to enact laws or policies, guarantee financial support, establish reasonable charging standards for the service, and enhance reward for healthcare providers, thus to encourage them to engage in home hospice care.