Objective To optimize the handover process and realize seamless patient handover by developing a surgical patient transfer and handover system. Methods From April to July 2019, traditional face-to-face verbal communication or telephone communication were used for surgical patient transfer and handover. From April to July 2020, a transfer and handover system for surgical patients was designed and implemented into clinical practice:using information technology to optimize patient handover, pushing handover information synchronously to relevant staff, identifying patient through barcode, and supervising the whole patient transfer flow. Results After using the system, duration for patient transfer to the operating room, the interval between consecutive surgeries, and the incidence of adverse events during the transfer were significantly decreased, whereas nurses′ and workers′ satisfaction were significantly enhanced (P<0.01 for all). Conclusion The application of surgical patient transfer and handover system optimizes the handover process and makes all links more standardized, precise, and efficient.