Objective To understand the status and influencing factors of couple disease communication among stoma patients with colorectal cancer, and to provide reference for improving intervention effect of couple disease communication. Methods Totally 221 colorectal cancer patients with stoma were conveniently selected, then they were investigated using the general information questionnaire and Cancer-related Communication Problems Scale. Results The total score of couple cancer related communication among colorectal cancer patients with stoma was （17.10±5.20）.Multiple linear regression analysis showed that, monthly income, TNM staging, self-care ability and stoma time were the influencing factors of disease communication among stoma patients with colorectal cancer （P＜0.05，P＜0.01）. Conclusion The disease communication of stoma patients with colorectal cancer is at a medium level.The patients with low income, advanced stage of cancer, short stoma time and low self-care ability are prone to experience disease communication problem with their spouses. It is suggested to develop targeted couple communication training program, so as to improve couple communication problems.