Objective To construct a demand-oriented chronic wound management model based on specialized alliance, and to evaluate its practice effect. Methods According to field investigations, questionnaire surveys and qualitative interviews, a chronic wound management model based on specialized alliance was constructed, which was then applied to the chronic wound management in the alliance area.The practice effect of the constructed model was evaluated according to the implementation of the alliance work, the cost of patient treatment and patient satisfaction in grass-root hospitals after application for 10 months. Results During the running period of the model, the leading hospital conducted 13 times on-site technical guidance for the alliance member hospitals, 102 times remote consultation, 6 times on-site consultation and online teaching, received 23 person-times further education, and cultivated 57 wound care specialty nurses.The average economic and time cost of chronic wound patients were significantly lower, and their satisfaction in grass-root hospitals was significantly higher than those before application of the management model (P＜0.05，P＜0.01). Conclusion The chronic wound management model based on specialized alliance reduces patients′ medical cost, improves patient satisfaction in grass-root hospitals, so it is conducive to the integration of health resources in the alliance region, then realize high-efficient management for chronic wound in the region.