Objective To analyze the effects of using App to give health education to patients receiving femtosecond laser small incision lenticule extraction (SMILE). Methods A total of 1 053 patients to receive SMILE from March 2016 to December 2017 were enrolled into the control group, who received traditional health education. Another 1 458 cases from January 2018 to June 2020 were assigned into the intervention group, who received App-based health education:a health education team was established, and gave health education to patients through the 5 modules of online clinic appointment scheduling, library for specialty-oriented knowledge, surgery simulation, reminders, and health consultation. Results The visual acuity recovery rate after surgery, medication compliance and satisfaction score in the intervention group were significantly better than those in the control group (P<0.01 for all). Conclusion App-based health education in patients receiving SMILE effectively improves visual quality, medication compliance and satisfaction of patients.