Objective To formulate a self-disclosure oriented benefit finding intervention protocol for breast cancer patients, and to provide a guidance for psychological rehabilitation. Methods The draft of intervention protocol was developed after literature reviewing, then it was revised through structured interviews and expert meetings with breast cancer patients, nurses and experts. Finally, a pilot randomized controlled study was conducted on 30 breast cancer patients. Results The intervention protocol included six-section self-disclosure intervention, in which main objective, instructive disclosure outlines and auxiliary interventions were listed. The expert authority coefficient was 0.812. Ten patients completed the six-section interventions. The intervention group had higher satisfaction and greater improvement in benefit finding and cognitive evaluation compared with the controls (P＜0.05，P＜0.01). Conclusion The benefit finding intervention protocol for breast cancer patients is practical and effective, but it needs further improvement and large-sample validation.