Objective To explore the management strategies for safe transport of COVID-19 patients. Methods We transported 1 487 COVID-19 patients. During the transportation, thorough planning, careful patient preparation and equipment preparation, strict disinfection and protection were conducted. Results All the patients were transported to the designated rescue hospital safely. No worker who participated in the transportation was infected. Conclusion Thorough arrangement and strict disinfection and isolation guarantee safe transport of COVID-19 patients.