Objective To understand the current status of psychological detachment of caregivers of maintenance hemodialysis patients and the influence factors. Methods A questionnaire survey was conducted among caregivers of 205 maintenance hemodialysis patients by using Psychological Detachment Scale, Zarit Burden Inventory and Warwick-Edinburgh Mental Well-being Scale. Results The caregiver scored （12.01±3.57） in psychological detachment, which was influenced by such factors as caregiving years, self-reported personality type, caregiver burden, positive mentality, patient dialysis years and dialysis complications（P＜0.05，P＜0.01）. Conclusion The caregivers of maintenance hemodialysis patients have a moderate level of psychological detachment, which is influenced by the following factors of caregiving years, self-reported personality type, caregiver burden, positive mentality, patient dialysis years and dialysis complications. Medical staff should pay attention to psychological detachment of caregivers, take active measures to improve their psychological detachment, and promote their physical and mental health.