Objective To enhance ICU nursing care knowledge and skills levels of nurses on medical teams to be mobilized to aid Hubei, and to lay to lay the foundation of intensive care skills for their anti-coronavirus service in Hubei province. Methods A trainer group was set up in the ICU to deliver trainings to 100 nurses who were to head for Hubei to help combat novel coronavirus outbreak. The two-week training contents were divided into 10 modules, including infection control, airway management, intravenous therapy, nutrition support, analgesia and sedation, blood purification, pulmonary rehabilitation, hemodynamics monitoring, cardiopulmonary support, and the reception and transportation of critically ill patients, according to the characteristics of severe COVID-19 pneumonia. Results After the training, the written exam and skill exam scores of the nurses were (85.59±3.52) and (88.62±5.53) respectively, and the scores of core competence were significantly higher than those before the training (P<0.01 for all). Totally, 49 nurses left for Hubei and took part in the front line treatment of 33 severe COVID-19 pneumonia patients. None of the nurses contacted the contagion. Conclusion Module-based teaching, which covers comprehensive contents and gives prominence to the key points, is very effective in short-term crash training course for nurses of medical teams to be mobilized to aid Hubei.