Objective To investigate and analyze prevention and management of skin injuries associated with the use of personal protective equipment among medical staff fighting against COVID-19，and to provide references for countermeasures. Methods A self-designed questionnaire was launched in Wenjuanxing website and accessed by front-line medical staff fighting against COVID-19. The occurrence of skin injuries associated with the use of personal protective equipment, the characteristics of the injuries, prevention and management measures were analyzed. Results A total of 2 901 medical staffers completed the questionnaire survey, and 1 069 staffers developed 2 794 lesions of skin injuries. The incidence rate for skin injuries, pressure injuries, moisture-associated skin damage and skin tear stood at 36.8%（95%CI 35.1%-38.6%）,26.6%（95%CI 25.0%-28.2%）,8.8%（95%CI 7.8%-9.8%），1.5%（95%CI 1.0%-1.9%） respectively. The incidence rate of skin injuries caused by wearing level 1,level 2 and level 3 personal protective equipment was 9.5%, 43.1% and 85.8%,respectively, with the difference being statistically significant (P<0.01). Only 380 staffers (13.1%) took preventive measures for skin injuries: 3.7%(107/2 901) used foam dressing, 5.8% (169/2 901) used hydro-colloid dressing, and 5.9% (170/2 901) used oiling agents. In 1 069 cases with skin injuries, 57.0% used different methods to manage the injuries. Conclusion The incidence rate of skin injuries, which were predominantly pressure injuries, followed by moisture-associated skin damage, in medical staff wearing level 2 and 3 protective equipment was high. The prevention and management measures they used were insufficient and non-standard. It is suggested to ramp up management from organizational and individual levels, and take effectively measures to keep the skin healthy for front-line medical staff fighting against COVID-19.