Objective To explore the effects of setting up a specially designated nurse in standardized management of chemotherapy induced nausea and vomiting （CINV). Methods A total of 489 breast cancer patients undergoing chemotherapy were assigned into a control group of 235 and an intervention group of 254 according to their admission time, receiving either routine care or standar-dized management provided by special nurse who was designated to undertake CINV care. Results The degree of CINV was significantly milder, whereas patients′ compliance and satisfaction were significantly higher in the intervention group compared with the control group（P＜0.05,P＜0.01）. Conclusion Setting up a specially designated nurse for whole-course management of CINV in breast cancer patients ensures the accuracy of dynamic assessment of CINV and ameliorates severity of CINV.