Objective To explore the effect of perioperative nutritional risk screening and nutrition intervention for children with Hirschsprung′s disease (HD) under the concept of Enhanced Recovery After Surgery (ERAS). Methods A total of 113 HD children were divided into a control group of 45 cases and an intervention group of 68 cases according to chronological order of admission time. The control group received routine nursing care, while the intervention group received ERAS based nutrition intervention by a nutrition-specialist-led nursing team. The nutritional indicators and incidence rate of postoperative nutritional-related complications were compared between the two groups. Results Compared with the control group, the nutritional indicators of the intervention group were significantly improved on the 3rd postoperative day and the first postoperative week, the incidence rates of postoperative nutritional-related complications were significantly lower, and the time to start oral food intake, ventilation time and the average hospital stay postoperatively were significantly shorter (P<0.05，P<0.01). Conclusion Perioperative nutrition risk screening and nutritional support under ERAS concept can effectively improve nutritional status of HD children, reduce the incidence rate of postoperative nutrition-related complications, and accelerate postoperative recovery.