Objective To apply the best evidence of prevention and management of medical adhesive-related skin injury (MARSI) to elderly patients clinically, and to boost nursing quality improvement through quality reviews. Methods In the prospective controlled study, the best evidence of MARSI prevention and management for elderly patients was summarized. Then 10 review indicators were established. Evidence-based nursing practice was pushed through in pilot wards from July to November 2018. Through baseline review of 119 elderly patients (the baseline group), clinical obstacles were identified, and an evidence-based practice change protocol was constructed. Then the protocol was implemented to another 132 elderly patients (the implementation group). Results After the application of the best evidence, the implementation group was subjected to 2nd round quality review. The incidence rate of MARSI in the elderly patients decreased from 10.08% (baseline) to 0.76%, the incidence rates of skin itching, and pain after removal of the medical adhesive decreased from 19.33%, 39.50% to 2.27%, 3.79% respectively, with before-after differences being significant (P<0.01 for all). Nurses′ implementation rates and knowledge of the best evidence have been greatly improved. Conclusion The best evidence of MARSI prevention and management for elderly patients can standardize the usage of medical adhesive by nurses, reduce the incidence rate of skin injury in patients, and promote patient comfort.