Objective To explore and analyze consistency in attitudes towards advance directive regarding life-sustaining treatment, death place, and diagnosis informing, ect., between advanced cancer patients and their family members. Methods Totally, 268 pairs of advanced cancer patients and their family members were involved in the research through convenient sampling from oncology department of a 3A hospital in Beijing. Questionnaire of attitudes toward advance directive was used to measure consistency in attitudes towards advance directive between advanced cancer patients and their family members. Results Totally, 59% of the cancer patients would like to make an advance directive, and 88.4% of the family members would like to follow patients′advance directive if they make one. The Kappa value for consistency in attitude towards advance directive between advanced cancer patients and their family members was 0.010. And the consistency in attitudes towards life-sustaining treatment, death place, and diagnosis informing were very low (Kappa values were 0.158-0.235，0.227，0.056 respectively). Conclusion Consistency in attitudes towards advance directive between advanced cancer patients and their family members was low. Family members′ attitudes towards life-sustaining treatment, death place, and diagnosis informing can′t represent patients′own attitudes. Medical staff should strengthen communication with patients and family members, so as to promote their consistency in the attitudes towards advance directive.