Objective To explore the relationship among chemotherapy-induced peripheral neuropathy (CIPN), balance function and quality of life in gynecologic cancer patients, and to provide corresponding reference for patient intervention during chemotherapy. Methods A convenient sampling method was used to select 219 patients with gynecologic cancer from a hospital in Tianjin. The general information questionnaire, the Chemotherapy-induced Peripheral Neuropathy Assessment Tool, the Berg Balance Scale, The European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ-C30 ) were used for survey. Results The CIPN symptom scores in gynecologic cancer patients was （83.08±47.74）points, and CIPN scores on ADL was（41.35±20.59）points; 68.49% of the gynecological cancer patients were at risk of falls. Patient′s quality of life scored（50.65±17.74） points. The CIPN symptom experience scores and the CIPN interference scores were significantly higher in patients with risk of falls than those without such risk（P＜0.01 for all）. Correlation analysis showed that the overall quality of life of gynecologic cancer patients was negatively correlated with CIPN symptom experience scores and the CIPN interference scores （P＜0.01 for all）. Conclusion CIPN, which is common in gynecological cancer patients, affects the daily activities of patients, increases the risk of falls and cause a decline in their quality of life to some extent. Clinical workers should take timely and effective measures to intervene peripheral neuropathy, so as to improve the quality of life of patients.