Objective To explore the relationship between ethical sensitivity and perceived professional benefits in nurses working in 3A hospitals, and to provide references for nursing administrators to improve nurses′ perceived professional benefits, and stabilize the nursing team. Methods Totally, 422 nurses from 3A hospitals were selected. The Chinese Moral Sensitivity Questionnaire-revised version （MSQ-R-CV） and Nurses′ Perceived Professional Benefits （NPPB） were used to assess nurses′ ethical sensitivity and perceived professional benefits respectively. Results Nurses scored (35.78±7.86) points in ethical sensitivity, and (111.81±18.41) points in perceived professional benefits, with the total scores of the 2 variables being positively correlated （r=0.369,P＜0.01）. Conclusion Nurses′ ethical sensitivity working in 3A hospitals was positively correlated with their perceived professional benefits, indicating improvement of nurses′ ethical sensitivity is helpful to enhance their perceived professional benefits.