Objective To investigate the status of chemotherapy-induced taste alterations, nutrition levels and quality of life among gastrointestinal cancer patients, to analyze the relationship among the 3 variables, and to provide references for targeted intervention. Methods The Chinese version of the Chemo-related Taste Change Scale, the Nutritional Risk Screening Table and the Quality of Life Scale were used to investigate 342 patients with gastrointestinal tumors to assess changes in the taste of the patients and analyze how taste alterations exert influence on patients′ nutritional risks and quality of life. Results A total of 283 (82.75%) patients had taste alterations. The total and dimension scores of taste alterations in high nutrition risk group were significantly higher than the low risk group (P＜0.01 for all). Taste change scores were negatively correlated with overall health status and functional dimension scores, and positively correlated with multiple symptom dimension scores (except the dimension of financial difficulties) （P＜0.01 for all）. Conclusion The incidence of chemotherapy-related taste alterations in patients with gastrointestinal cancer is high, and it has a negative impact on the nutrition and quality of life of patients.It needs to be addressed by medical staff.Targeted measures should be taken to lessen the ramification of taste alterations.