Objective To explore the effect of using mobile health technology in transitional care of liver transplant recipients. Methods Transitional home care was provided to 30 liver transplant recipients by using a self-developed remote follow-up management system during two weeks post-discharge. Results The medical team was able to remotely monitor patients′ conditions post-discharge, and delivered 353 times of guidance to the patients through live video communication; 81.08% of the recipients deemed the system acceptable, and all grasped the usage of the system; the average usage length was (10.53±2.50) days, and the average video communication length was (12.14±2.70) minutes each time. The 3 features that most satisfied the medical team included handling of changes in patients′ conditions, availability of live video communication, contents of counseling and guidance; the 3 features that most satisfied the patients included availability of live video communication, transitional care mode, contents of counseling and guidance. Conclusion The application of remote follow-up management system in the transitional care of liver transplant recipients is feasible and effective.