Objective To explore the effects of group mindfulness-based stress reduction therapy on stigma and sleep quality in patients with depression. Methods Totally, 160 depression patients were evenly divided into two groups according to the random number table. The control group received routine nursing care in the department of medical psychology, while the intervention group additionally received group mindfulness-based stress reduction therapy. Perceived Devaluation-Discrimination Scale （PDD）, Pittsburgh Sleep Quality Index （PSQI）, Hamilton Depression Scale （HAMD） and Simple Coping Style Questionnaire （SCSQ） were used to respectively evaluate the stigma level, depression level and sleep quality of the two groups at admission and before discharge. The effects of different nursing interventions on the stigma and sleep quality between the two groups were analyzed. Results After the intervention, the scores of perceived devaluation-discrimination, sleep quality and depression in the intervention group were significantly lower than those of the control group （P＜0.01 for all）; the positive coping scores in the intervention group were significantly higher, and the negative coping scores were significantly lower, than those of the control group （P＜0.01 for both）. Conclusion Group mindfulness-based stress reduction therapy can reduce stigma and improve sleep quality in patients with depression.